The histone acetyltransferase p300 promotes intrinsic axonal regeneration
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Histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene.
Previous studies have revealed that histone acetyltransferase p300 is recruited to the promoters of certain cardiac and smooth muscle specific genes to enhance the transactivation activity of myocardin, which is a master regulator in cardiovascular differentiation and development. Here, we found that the gene encoding catechol-O-methyltransferase (COMT), an important metabolic enzyme catalyzing...
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ژورنال
عنوان ژورنال: Brain
سال: 2011
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awr142